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Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration

"Our understanding of the role of bone marrow (BM)­ derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM con­ tributes a significant proportion of noninflammatory cells to the skin, which are present primarily in the dermis in fibroblast-like morphology and in the epidermis in a keratinocyte phenotype; and the number of these BM-derived cells increases markedly after wounding. More recently, several studies indicate that mesenchymal stem cells derived from the BM could significantly impact wound healing in diabetic and nondiabctic animals, through cell differentiation and the release of paracrine factors, implying a profound therapeutic potential. This review discusses the most recent understanding of the contribution of RM-derived noninflammatory cells to cutaneous homeostasis and wound healing." Source:

Wu, Y., Zhao, R. C., & Tredget, E. E. (2010). Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem cells, 28(5), 905-915.

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